The ascendancy of the bioeconomy is linked to the actions, prioritization, and guidance of policymakers and regulatory bodies. The regulatory milieu for synthetic biology remains in flux, covering many sectors such as food, energy, materials, and pharmaceuticals. Furthermore, bioeconomy-oriented policies are pivotal in stewarding natural ecosystems, conserving biodiversity, and ensuring biosecurity. In an epoch characterized by climatic perturbations, dwindling resources, and burgeoning global health threats, the formulation of cogent, resilient, and informed bioeconomy policy frameworks becomes indispensable for a sustainable, safe, and secure economy.