Synthetic biology is at the forefront of revolutionizing our approach to engineering microorganisms that benefit both humans and the environment. By seamlessly integrating with metabolic engineering and systems biology, it gives rise to systems metabolic engineering. Systems metabolic engineering significantly enhances the efficiency of strain development. In this presentation, Sang Yup Lee elucidates the strategies of systems metabolic engineering and its diverse applications. He highlights various exemplary products, from bulk chemicals to polymers and natural products, underscoring their contributions to health and sustainability, and concludes with a discussion on the future prospects of this promising field.