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Mammoth Biosciences Signs Agreements with MilliporeSigma and Hamilton Company Targeting Commercialization of High-Throughput CRISPR-based SARS CoV-2 Test

The company has signed agreements with MilliporeSigma to scale manufacturing and with Hamilton Company to market a turnkey solution to help CLIA laboratories rapidly add testing capacity

South San Francisco, Calif. – WEBWIRE – Thursday, October 29, 2020

Mammoth Biosciences, Inc., today announced that it has signed agreements with MilliporeSigma and Hamilton Company targeting commercialization of a high-throughput CRISPR-based SARS CoV-2 test. The test leverages Mammoth’s DETECTR BOOST™ platform and will provide a sample-to-answer turnkey solution for commercial laboratories to enable a multi-fold increase in testing capacity.

As laboratories nationwide face limited capacity and testing supply shortages amid the pandemic, Mammoth Biosciences is poised to help reduce the backlog by working with leading manufacturing and automation vendors for its CRISPR-based SARS-CoV-2 molecular assay. The high-throughput systems will be compatible with both nasal swab and saliva samples and are targeting 1500 tests per 8-hour shift with minimal user interaction. Mammoth Biosciences plans to submit the assay for FDA Emergency Use Authorization later this year.

“In order to begin reopening more aspects of society, we’ll need a robust testing infrastructure that can rapidly scale up capacity as needed,” said Trevor Martin, Ph.D., co-founder and CEO of Mammoth Biosciences. “By combining CRISPR-based diagnostics with the proven manufacturing and product leadership of MilliporeSigma and Hamilton Company, we’re confident this solution will be a game-changer for labs.”

Mammoth’s DETECTR BOOST™ SARS-CoV-2 assay reagent kits, which will be contract manufactured by MilliporeSigma, rival PCR in sensitivity while being less prone to supply chain risk. The testing system will also leverage standard, automated liquid handling equipment such as those from Hamilton Company to enable rapid processing of patient samples. By implementing this unique offering, CLIA laboratories will be able to significantly improve their capacity to regularly test communities and businesses in need.

“This collaboration will allow us to help Mammoth with the development and production of their new SARS-CoV-2 test, which, once approved by the FDA, will increase testing capacity here in the U.S. at the scale needed to combat this pandemic,” said Jean-Charles Wirth, head of Applied Solutions at MilliporeSigma. “MilliporeSigma is helping to advance the future of testing at scale. This is an important step in detecting Covid-19 quickly.”

The announcement comes after Mammoth secured a contract from the National Institute of Health’s RADx program to scale its high-throughput CRISPR-based testing workflow.

Those individuals or CLIA laboratories interested in learning more about the Mammoth high-throughput CRISPR-based SARS CoV-2 platform should go to

This project is supported by the NIH Rapid Acceleration of Diagnostics (RADx) program and has been funded in whole or in part with Federal funds from the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Department of Health and Human Services, under Contract No. 75N92020C00011.

About Mammoth Biosciences

Mammoth Biosciences is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. By leveraging its internal research and development and exclusive licensing to patents related to Cas12, Cas13, Cas14 and Casɸ, Mammoth Biosciences can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in South San Francisco, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate, Jennifer Doudna, along with Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Decheng, Mayfield, NFX and 8VC, and leading individual investors including Brook Byers, Tim Cook and Jeff Huber.

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Riley Munks
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