June 26, 2018

The sky is not the limit: What synthetic biologists can learn from astronaut Scott Kelly

https://www.nasa.gov/image-feature/scott-kelly-becomes-us-astronaut-to-spend-the-most-time-in-space

“At 6 seconds, the main engines light, 3 giant engines with a million pounds of thrust. But you don’t go anywhere, because you’re bolted to the launch pad with 8 giant bolts. Then the clock goes, 5, 4, 3, 2, 1… At 0, simultaneously, those solid rocket motors are lit, those bolts are exploded open, and it feels like the hand of God has lifted you off that launch pad and is throwing you into outer space.”

Former astronaut Scott Kelly is a dreamer.

A retired U.S. Navy Captain, he’s best known for his “year in space,” the 342-day research project on the International Space Station (ISS) to study the health effects of long-term space flight. The NASA Twins Study on Scott and his identical twin brother Mark hit viral fame.

I had the pleasure of seeing him speak at McCaw Hall in Seattle, where he discussed the core values that drive him. His underlying message: the importance of reaching, sometimes literally, for the stars.

“The best part about being an astronaut and about flying in space, for me, was that it’s really, really hard. It was about having goals within a plan. It was about taking risks. Being willing to make mistakes. At times, being willing to fail. It was about focusing on things that I could control and ignoring what I couldn’t.”

Life scientists can learn a lot from Scott.

Synthetic biology is hard. It’s risky. Lab-grown organs, three-parent babies, data storage in DNA – some of it sounds borderline insane. There’s controversy. There’s politics. But at its core, synthetic biology is about taking inspiration from the mechanisms of nature and expanding it with technology, all to transform our world for the better. That means less disease, higher quality of life, and a healthier planet.

If you think that sounds idealistic, you’re right – but that doesn’t mean it can’t be done.

This field is full of no-nonsense idealists. Toxic waste-eating bacteria, cutting-edge vaccines, super-sensitive bionic limbs, plants redesigned to feed the world, sustainable spider silk fabric, molecules designed by nature and engineered into life-saving malaria drugs – these incredible innovations sound like they came straight out of a sci-fi short story anthology. But they’re happening, and it’s because of researchers who are willing to push the envelope.

Most papers in the sciences discuss their “findings”. But synthetic biology isn’t just about finding things – it’s about creating them.

The key is being willing to do what seems impossible.

“When I was a kid growing up,” Scott says, “I was a really, really bad student.

“I graduated from high school in the bottom half of my class. I went on to college because that’s what was expected of me.”

It wasn’t until he was 18 and read, on a whim, “The Right Stuff” by Tom Wolfe, that he found the inspiration he needed to apply himself in school. He buckled down, went on to graduate as an engineer in the Navy, made his way to Pensacola, FL to be a fighter pilot – he failed his first test, by the way, after crashing his F-14 Tomcat while landing on an aircraft carrier – and finally was accepted to the NASA space program in 1996.

In December 1999, Scott found himself on the launch pad for his first journey into space, on a repair mission for the Hubble Space Telescope.

“When we get into space after 8 and ½ minutes, we’re flying around the earth at 17,500 miles per hour. As the sun came up, I saw how breathtakingly beautiful our planet Earth is. Almost like someone took the most brilliantly blue paint, and painted it on the air right in front of my eyes. I knew right then and there I’d never see anything as beautiful as planet Earth again.”

It took 18 years, but he’d gone from the bottom of his class to the top of the world.

Earth

On the importance of dreaming big

Always challenging the status quo is what drove Scott through his career. If he had allowed himself to get comfortable, he’d probably still be in Florida, maybe flying cargo planes. He took a risk – retaking his Tomcat test even though he’d lose his Navy career if he failed the second time – and it paid off.

The famed year-long mission ended in March 2016, but these lessons have stuck with him.

“When I was leaving for the last time, I’m looking out the window, and I’m thinking about how we built this space station. A million pounds, flying around the earth at 17,500 mph in a vacuum in extremes of temperature of +/- 270 degrees, built by this international partnership of 15 different countries This space station is the hardest thing we’ve ever done. Harder than going to the moon.”

“If we can do this, we can do anything.

“If we wanna go to Mars, we can go to Mars. If we want to cure cancer, we can do that. After spending a year in space, I was absolutely inspired that if we can dream it, we can do it.”

On seeing the Big Picture

“When you’re in space and you’re detached from the Earth, you get this different perspective on our planet. We had days when I was in space this last time, with beautiful flyovers of the Mediterranean, with the very deep blue color of juxtaposed against the northern deserts of Africa, and it’s absolutely breathtaking. And then I’d watch the news at night and see little kids, refugees washing up on shore. And I’d think, why can’t we do something about this? Why can’t we solve those kinds of problems?”

“We can do so many brave things when we put our minds to it. I think being in space for a long time, and appreciating that, is something that most astronauts get. It is a privileged position and it’s unfortunate that more people can’t experience that; I think we would all be better for it.”

This perspective should certainly resonate with synthetic biologists. The field – a collaboration between plant and animal biologists, engineers, geneticists, computer scientists, and more – is ultimately about solving those high-level problems. It’s about doing the hard things, working together, challenging the status quo, and being persistent in the fight to better our world – even when it sounds impossible.

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