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Sr. Scientist – Inscripta, Pleasanton, CA

Description

Inscripta is developing the world’s first scalable platform for benchtop Digital Genome Engineering. The company’s advanced CRISPR-based platform, consisting of an instrument, reagents, and software, will offer a fully automated workflow that enables multiplexed, trackable editing of cells at an unprecedented scale. Inscripta’s goal is to empower scientists whose gene editing research is stifled by current technical and licensing limitations. By providing this unique platform and engaging in collaborative business practices, such as making its MAD7 CRISPR nuclease free for research purposes, the company enables scientists to realize a new era of biological discovery.  Due to rapid growth Inscripta has an opening for a Sr. Scientist located Pleasanton, CA

Summary:

The ideal candidate will have demonstrated experience in the design, development and manufacturing transfer of custom NGS-based assays for enriching and quantifying nucleic acids. S/he will become a core contributor to integrated, multidisciplinary teams developing new CRISPR-based, DNA editing technology platforms (software, instruments and reagents). A successful candidate will also serve as both an individual contributor and project team lead for assay development projects in a dynamic, team-oriented environment.

Responsibilities:

  • Lead the design and development of novel NGS-based target enrichment assays for mammalian systems, with a particular focus on quantifying nucleic acids in single cells.
  • Design, develop and analyze non-sequencing-based assays (e.g. ddPCR and/or Sanger sequencing) for quantifying or characterizing nucleic acids.
  • Work collaboratively with mammalian cell biologists, molecular biologists and data scientists to define and develop measurement assays and associated controls.
  • Support implementation of data processing and analysis workflows, bioinformatics pipelines and laboratory data management systems in collaboration with internal, multidisciplinary teams.
  • Perform Gauge R&R, verification, validation and transfer of assays from R&D to manufacturing.
  • Effectively direct, organize and manage workload as needed to achieve timely execution of assay development projects.
  • Present clear and concise written and oral communication to colleagues, lead and/or participate in technical meetings and provide recommendations based on technical results.
Requirements

Required Educational Background and Work Experience:

  • Ph.D., Cell and/or Molecular Biology, Biochemistry, Bioengineering or closely related field with expertise in mammalian cell biology/genomics.
  • Must have a minimum of 6 years industry experience with hands-on (wet lab) NGS assay design and development including analysis and reporting of data for mammalian biology/genomics applications.

Required Skills and Experience:

  • Must have in-depth knowledge and experience developing assays for Illumina NGS platforms and technologies, including MiSeq and NextSeq instrumentation and reagents.
  • Must have prior experience developing single cell NGS assays using single cell sequencing preparation technology, such as 10X Genomics, Mission Bio or similar.
  • Must be familiar with different NGS software platforms, bioinformatics pipelines and NGS data processing and interpretation solutions.
  • Must be able to design and execute critical experiments against a development plan, including data analysis to draw meaningful conclusions.
  • Must have strong organizational skills and ability to work collaboratively in a matrixed team environment.
  • Must be self-motivated and able to adapt to changing priorities and technical challenges in a fast-paced environment within an interdisciplinary team setting.

Inscripta offers a competitive base salary, bonus plan, benefits package and stock options to all team members.  Join us and work with a great team of people developing the world’s first scalable platform for benchtop Digital Genome Engineering. Inscripta is headquartered in Boulder, CO with offices in Pleasanton and San Diego, CA.  This position is located in our Pleasanton, CA location.

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