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Sr/Principal Scientist, Gene Therapy & AAV Engineering: Codexis – Redwood City, CA

In the BioTherapeutics group at Codexis, we create novel biologics for the treatment of rare genetic disorders. Using our world leading CodeEvolver® protein engineering platform, we discover proteins and the corresponding transgenes with high efficacy and safety with the aim of delivering the protein to patients as a nucleic acid or protein therapy.

Our first program yielded CDX-6114, an orally administered, GI-active enzyme therapy for potential treatment of phenylketonuria. This program has been licensed to Nestlé Health Science. In addition, we have Strategic Discovery Collaborations with Takeda on improved transgenes, and Nestlé Health Science on other GI-directed discovery programs. At this time, we seek a highly motivated scientist with experience in AAV engineering to help us build our Gene Therapy program in the Biotherapeutics Lead Discovery team.

We are looking for an experienced scientist to join our gene therapy research efforts. Successful candidates will be part of an interdisciplinary, dynamic and enthusiastic biotherapeutics discovery team responsible for implementing Codexis’ core technologies to deliver candidate biologics.

Responsibilities include:

  • Lead the design and implementation of AAV capsid evolution strategy.
  • Serve as technical lead for AAV capsid and promotor engineering programs.
  • Develop and optimize assays for combinatorial AAV libraries; miniaturize assays and apply to high-throughput screening.
  • Produce, purify, and evaluate engineered capsid variants.
  • Interface with contract research organizations (CROs) to supplement internal capabilities.
  • Train, support, and, if required, supervise junior team members.
  • Actively participate in project teams, present research updates, and collaborate with cross-functional team members. Keep diligent records and write reports and SOPs.

Job Requirements:

  • PhD in Biology, Biochemistry, Bioengineering, or related field with >5 years of experience in AAV-based gene therapy.  Level of hiring will be based on the candidate’s experience and capabilities.
  • Extensive knowledge of AAV biochemistry including a deep understanding of capsid structure-function, transgene design, promoters, differences amongst serotypes, and immunogenicity considerations.
  • Experience designing, building, and screening libraries of AAV variants. Applications with directed evolution or machine learning desired.
  • Broad experience in mammalian cell culture, cell-based assays, and biochemical characterization methods.
  • Familiarity with AAV manufacturing practices and preclinical gene therapy models desired but not required.
  • Able to work highly independently under tight timelines in a collaborative team setting.
  • Excellent interpersonal and communication skills.

The position comes with a competitive compensation and benefits package, including paid company holidays, paid time off, health benefits, 401k match, and much more.  For more information about our plans for the future, and to be considered for this career opportunity, please visit www.codexis.com.

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Lio Tariman

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