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Senior Scientist, Strain Engineering: AbSci – Vancouver, WA

AbSci is a growth stage synthetic biology company located in a new, state-of-the art laboratory in downtown Vancouver, WA, just across the river from Portland, OR.  AbSci is a global leader and innovator of revolutionary biomanufacturing technologies, designing and programming cells for next-generation biopharmaceuticals. Our Protein Printing™ technology results in dramatic reductions in the cost of producing biologics, acceleration of drug discovery timelines, and enables the production of previously difficult or impossible-to-produce molecules.

Job Description and Responsibilities:

The Sr. Scientist will focus on innovation and further development of the capabilities of AbSci’s proprietary E. coli SoluPro® expression platform and high-throughput strain optimization workflow.    The ideal candidate is a visionary synthetic biologist and strain engineer who will leverage the modern E. coli genetic toolbox, modern DNA construction technologies, bioinformatics, and high-throughput screening methods to push the boundaries of AbSci’s Protein Printing™ technology.  The ideal candidate has excellent collaboration skills, a creative approach to problem-solving, exhibits superior people and program management skills, and can execute nimbly and efficiently in a dynamic startup environment.

Responsibilities:

  • Work with the Molecular Science team to advance technical priorities
  • Design and build genetic tools and E. coli SoluPro® strain derivatives that enable AbSci to exceed next generation biomanufacturing performance criteria.
  • Analyse AbSci library screening, -omics, and related data sets to inform strategies that improve protein titer and quality for select protein therapeutics.
  • Provide technical support and strategy for DNA library construction, strain engineering, assay development, and high-throughput screening teams.

Skills and Qualifications:

  • Ph.D. in the life sciences, with a focus in synthetic biology, bacterial genetics, bioinformatics, molecular biology, or a similar field.
  • 4+ years of industry experience is preferred.
  • Extensive experience with modern bacterial strain engineering technologies and approaches.
  • Extensive experience with modern DNA construction techniques (Golden Gate, Gibson) and plasmid design tools (Geneious).
  • Familiarity with -omics platforms, including hardware, data, and informatic tools for analysis.
  • Extensive experience with high-throughput workflows, laboratory automation, and complex data sets.
  • Familiarity with recombinant protein expression in E. coli is preferred.
  • Passion for building a gritty and creative company culture that is collaborative, multidisciplinary, and determined to make a transformative impact on our industry.

We seek candidates with a passion for building a creative company culture that is collaborative, multidisciplinary, and committed to make a transformative impact in our industry.  To be successful in this role, we look for a demonstrable track record of taking ownership, strong interpersonal skills, attention to detail, a sense of urgency, and excitement about working in a dynamic startup environment.  A history  of success in functioning as part of a project team is essential.  AbSci offers highly competitive salaries and comprehensive benefits, including medical and dental insurance, paid time off, and 401(k) with a generous company match.

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Lio Tariman

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