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Scientist: Palamedrix – San Diego, CA

The cell phone sitting in your pocket is a modern miracle. It dominates every aspect of your life, from driving, to dining, to dating. At heart, your cell phone is the answer to a question:

What would be possible if we could integrate billions of transistors with light and motion sensors, a high-resolution display, and access to a radio network? 

Fifty years ago, few anticipated that the answer would be so central to our lives. Today, we at Palamedrix believe that fifty years from now, our lives will be deeply impacted by a new question:

What would be possible if we could integrate billions of biological molecules with those billions of transistors? 

If history is a guide then reality will exceed our imaginations, but science fiction has provided a glimpse: the Star Trek tricorder is something like a cell phone but, because of its interface to biologically important molecules, it has the magical ability to diagnose any disease, and could measure every aspect of their health, from fitness to fertility.

Inspired by such questions, Palamedrix has brought together a world-class team of experts in Next-generation sequencing, microfabrication, and molecular programming to leverage the unique power of DNA nanotechnology for developing a modular solution to counting all the different proteins in any fluids. The technology is designed to offer proteomics insights at a scale rivaling that of next-gen sequencing and across all scales to enable population-wide studies as well as single-cell studies. Development of our platform will require innovation in the areas of molecular sensors, sensor integration on CMOS chips, the microfluidic delivery of samples to these chips, chip-reading instrumentation, and data analytics. Palamedrix is building teams in all these areas and has core DNA-based technologies that provide for the integration of molecular biosensors onto chips. We are currently looking for forward-looking scientists and engineers to join our biochemistry team to develop hybrid DNA-protein biosensors that will power our first generation of products.

Over the next quarter, Palamedrix will hire two individuals for our biochemistry team which will:

  • Develop efficient strategies for the synthesis and purification of DNA-protein hybrid molecular sensors.
  • Develop analytical assays for the functional validation of the sensors using techniques such as gel electrophoresis, FPLC, qPCR, droplet digital PCR, ELISA, flow cytometry, and Next-generation sequencing.
  • Identify opportunities for process improvements, create IP, and implement these improvements.
  • Prepare internal project planning and technical reports, shaping both products and our roadmap.
  • Receive a high degree of autonomy and report directly to our CTO.

Ideally, members of our biochemistry team will have the following qualifications:

  • Advanced degree in Bioengineering, Biochemistry, DNA nanotechnology, Protein or Nucleic Acid Chemistry, Chemical Engineering or related scientific/engineering disciplines.
  • Ph.D. with a minimum of 2 years or MSc with a minimum of 5 years of experience in Life Sciences Industry.
  • Broad knowledge in the Biotech Industry, with experience in the rational design of protein complexes or nucleic acid nanostructures, as well as the coupling of nucleic acids to proteins.
  • Chromatographic expertise (e.g. with IEX, HIC, or SEC modes of HPLC/FPLC) preferably of recombinant proteins or monoclonal antibodies.
  • Assay development expertise (e.g. with ELISA, gel-electrophoresis, or qPCR) for protein or DNA quantification.
  • Purification expertise (e.g. with magnetic bead or column-based affinity separation of proteins).
  • A successful track record of developing complex protein or nucleic acid-based commercial products.
  • Demonstrated excellence in project planning, troubleshooting, communication, and collaboration.

Over the next year, Palamedrix will also be hiring for its microfabrication and instrument teams. Thus, we are also interested in individuals with crossover skills in areas such as: microfabrication, directed self-assembly, surface chemistry (especially the modification of semiconductors), atomic force microscopy, super-resolution microscopy, microfluidics, optical or electronic biosensors, and instrument building.

Palamedrix is an equal opportunity employer. Applicants will be considered without regard to race, color, sex, orientation, gender, presentation, religion, national origin, veteran status, or disability. As a company, we are dedicated to the intellectual, professional, and personal growth of our team members.  We will publish results with academic users of our technology in top journals, engage all team members with an opportunity to shape our strategic plans and provide flexible time off. Our lab is situated in San Diego, at Biolab’s Campus Point location.

If you are interested in being considered for one of these opportunities, please send a cover letter and a copy of your resume to hires@palamedrix.com


Lio Tariman

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