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Scientist – Genome Editing: Mammoth Biosciences, San Francisco


Mammoth Biosciences is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to democratize disease detection with an easy and affordable point-of-care test that allows real-time and simultaneous detection of multiple conditions. By leveraging its internal research and development and exclusive licensing to Cas12, Cas13 and Cas14, Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in San Francisco, Mammoth Biosciences is co-founded by CRISPR pioneer Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Mayfield, NFX, and 8VC, Decheng and leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.


Mammoth is seeking a Scientist with expertise in genome editing in cultured mammalian cells. The ideal candidate will have direct experience developing CRISPR systems; a strong background in genome editing and/or genome modulation in mammalian cells is essential. Candidates must be comfortable collaborating with others and prioritizing time, agendas, and projects to accomplish goals.

Initiate, direct, and perform experiments to advance the application of newly discovered CRISPR systems in mammalian cells
Develop CRISPR systems for genome editing
Interface with protein screening and biochemistry teams
Manage direct reports and collaborate with others on the team
Stay current in the field by participating in educational opportunities and reading relevant publications.
Think creatively about genome editing technologies

Ph.D. in relevant field with 3+years relevant experience
Strong background in tissue culture, molecular biology and cell engineering
Demonstrated experience with CRISPR in primary human cells using AAV and/or RNP delivery
Strong communication, presentation and data analysis skills
Highly motivated and detail-oriented individual with the ability to think creatively

Preferred Qualifications:
Experience with CRISPR spacer screens
Experience with NGS to characterize CRISPR editing outcomes and off-targets
Experience working with primary human cell lines
Experience with viral vector delivery such as AAV
Liquid handling automation experience

Competitive salary with equity
Full health/vision/dental benefits
Unlimited vacation
Free breakfast/lunch/dinner/barista
Free gym
Public transportation commuter subsidy
401(k) matching



Lio Tariman

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