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Research Scientist / Engineer 3 – In Vivo Studies, The Institute for Protein Design (Seattle,WA)

Natural proteins evolved over millions of years to solve the most complex challenges on Earth. However, we face new and pressing challenges today.

The goal of the Institute for Protein Design is to develop and apply methods for designing a whole new world of synthetic proteins to address these challenges.

To achieve this, we are marshalling deep institutional strengths in our faculty, scientific staff, postdoctoral fellows and graduate students, our partners from collaborating institutions, innovator networks and from the computer and biotechnology industries — bringing extraordinary expertise to bear on a singular focus to advance the potential of protein design.

The UW Institute for Protein Design currently has an outstanding opportunity for a Research Scientist 3 (RS3) to serve as the leader for in vivo small animal studies at the Institute for Protein Design (IPD). This Preclinical Research Scientist will provide a core competency in in vivo animal models at the IPD, thereby fulfilling a growing demand for the evaluation of the functional characteristics of designed proteins in vivo. The Preclinical Research Scientist will be assigned work under general guidance and receive instruction on specific assignment objectives, complex features, and possible solutions. Guidance on unusual problems will be provided to the Preclinical Research Scientist by IPD Faculty, other UW Faculty, or animal facilities employees who are experts in animal models, and work shall be reviewed for application of sound professional judgment.

The Preclinical Research Scientist will serve as the lead scientist in the IPD’s In Vivo Core lab, having oversight of collaborative preclinical in vivo research using small animal models to assess biodistribution, pharmacokinetics, safety, efficacy, and immunogenicity of computationally designed proteins and immunogens. This position will perform professional work in support of scientific research evaluating the characteristics of designed proteins in vivo in common small animal models.

In this role, ~60% of the effort will be dedicated to performing preclinical research evaluating the characteristics of designed proteins in vivo in common small animal models.

Another ~30% of effort will be dedicated to coordinating study designs and communicating the results and interpretations of each study with a number of internal collaborators at the IPD and in some cases external collaborators at other institutions.

The remaining ~10% of effort will be dedicated to continuous improvement of the In Vivo Core lab operations and standard operating procedures and interfacing with UW veterinary service personnel and the Office of Animal Welfare (OAW).

Minimum Requirements:

  • Master’s Degree in Biochemistry + 3 or more years of experience in related field.
  • The ideal Preclinical Research Scientist candidate will be someone who (i) selects and applies standardized scientific procedures and techniques to assignments of moderate to high complexity, involving potentially conflicting design requirements, (ii) continually learns and develops new in vivo methods and study designs, (iii) can manage individual research projects that they own, (iv) can provide timely and professional scientific services to a number of internal collaborators on several different projects, (v) can perform in vivo studies of novel molecules in a safe and humane manner, (vi) and enjoys interacting with other scientists in a highly collaborative and fast-paced work environment.

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Lio Tariman

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