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Preclinical Research Manager, Senti Biosciences (South San Francisco, CA)

Senti is a technology-driven therapeutics company here to lead the next generation of medicine—where cells are the hardware and gene circuits are the software. Programming cells to respond, adapt and make decisions, Senti is working to create smarter therapies with computer-like logic, enhanced functionality and greater control.

Senti Bio is seeking talented biologists to generate pre-clinical data in key disease models for our novel cell-based therapies. A successful applicant will be comfortable performing in vivo experiments and work collaboratively across various projects to meet milestones. Applicants should have current knowledge of molecular and cell biology, cell-based assays, and hands-on experience with in vivo mouse models of cancer or autoimmune diseases. Prior experience with cell-based therapies in a drug development setting is highly desirable. We are seeking individuals who are passionate about the future of “smart therapeutics” and have the energy and boldness to thrive and grow in a dynamic and fast startup environment.


    • Assist in planning, designing, executing and analyzing preclinical studies
    • Execution of experiment protocols using SOPs and performing data analysis with murine cancer models (tumor implantation, syngeneic, xenograft or PDX) and other disease models to support drug candidate discovery
    • Prepare and perform measurements relevant to disease models, including tumor inoculation, drug administration by ip, subcutaneous, oral or iv injection, mouse whole body IVIS imaging, primary immune cell isolation, tumor caliper measurement, blood and tissue collection, tissue processing, immunohistochemistry, immunofluorescence staining, flow cytometry and ELISA
    • Maintain clear and complete experiment records in compliance with internal SOPs and external regulations
    • Training and supervising research associates on the in vivo techniques, experiment workflow and professional development
    • Support scientific teams in multiple parallel projects
    • Support lab and vivarium operation and maintenance
    • Participation in and presentation at cross-departmental teams and project meetings


    • A Bachelor’s or Master’s degree in a scientific or technical field
    • At least 6+ years of research experience in a pharmaceutical company setting
    • In-depth experience and hands-on proficiency with mouse models of inflammatory disease or oncology
    • Expertise in handling small animals, drug administration, blood and tissue collection
    • Experience with cell culture (mouse/human tumor cells, mouse primary immune cells) and immunoassays
    • Demonstrated ability to work independently and as part of a multi-functional team
    • Experience managing direct reports
    • Strong communication and interpersonal skills



Lio Tariman

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