(2) Regular, Full-Time, RCUH Non-Civil Service positions with the John A. Burns School of Medicine, Institute for Biogenesis Research, located in Honolulu, Hawai‘i. Continuation of employment is dependent upon program/operational needs, satisfactory work performance, availability of funds, and compliance with applicable Federal/State laws.
- Forms and leads a rational design project with the purpose of improving transposase gene delivery.
- Improves the site-specificity of targeted integration into the genome by transposases using novel protein engineering methods.
- Works independently to design own research program and develops research plans.
- Conducts a wide variety of molecular biology techniques, some of which include: complex plasmid design and construction; lentiviral preparation and transduction; work with bacteriophage; Fluorescence-activated cell sorting (FACS); tissue culture including embryonic stem cell culture, southern and western blotting, and novel assays designed to test DNA binding and targeted insertion by transposases.
- Troubleshoots problems related to molecular biology.
- Performs data analysis and data interpretation.
- Prepares manuscripts and presentations of results for the scientific community and the public.
- Writes grant proposals.
- Trains and oversees undergraduate and graduate students.
- Manages general lab organization and maintenance.
- Presents data at lab meetings.
- PhD from an accredited college or university in Cell Biology, Molecular Biology, or related field.
- At least two (2) years of experience working on publications or projects demonstrating proficiency at protein engineering methods in a research laboratory.
- Evidence of a strong publication history with lead- author publications relating to studies involving integrating vectors or gene therapy techniques.
- Working knowledge of general principles of cell biology and molecular biology.
- Working knowledge of molecular biology techniques, such as complex plasmid design and construction, lentiviral preparation and transduction, bacteriophage, FACS, tissue culture, embryonic stem cell culture, and southern and western blotting.
- Ability to communicate well both orally and in writing.
- Ability to use common personal computer (PC) software for word processing (e.g., Microsoft Word), and database/spreadsheet (e.g., Microsoft Excel).
- Ability to organize PowerPoint presentations.
- Demonstrated ability to work independently, troubleshoot own problems, and generate research plans, publications and grant proposals.
Physical/Medical Requirements: Able to lift and carry up to twenty (20) pounds unassisted.
Policy and/or Regulatory Requirements: As a condition of employment, employee will be subject to all applicable RCUH policies and procedures and, as applicable, subject to the University of Hawai‘i’s and/or business entity’s policies and procedures. Violation of RCUH’s, UH’s, or business entity’s policies and/or procedures or applicable State or Federal laws and/or regulations may lead to disciplinary action (including, but not limited to possible termination of employment, personal fines, civil and/or criminal penalties, etc.).
Post Offer/Employment Conditions:
- Must be able to complete the UH Title IX training within twelve (12) months from date of hire.
- Must be able to complete the UH Laboratory Safety training within six (6) months from date of hire.
- Experience in the directed evolution field.
- Experience performing molecular biology techniques.
- Demonstrated ability to perform the following: gel electrophoresis, sequence analysis, polymerase chain reaction (PCR) optimization, and T7 assay.
RCUH’s mission is to support and enhance research, development and training in Hawai‘i, with a focus on the University of Hawai‘i.
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