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This 3-hour intensive session is designed for both newcomers and seasoned professionals in the Decentralised Science (DeSci) ecosystem. Participants will gain a comprehensive understanding of DeSci's core pillars, including funding, tooling, organization, data, publishing, and incentives. The session will also feature an inspiration session on the possibilities of how science can be defined and research conducted using DeSci, as well as a discussion on ethics in DeSci and how to maintain healthy morality while promoting progress and collaboration.